In vitro Micronucleus Service with Telomer Centromer Staining

Art. No.: SSA-O487TC

Service Analytics for 1 - X Compounds

Product Description

Service anayltics with in Vitro Mammalian Cell Micronucleus Test (MNT) according to OECD487 under GLP and non GLP conditions plus Telomere and Centromere Staining for the discrimination of aneugenic and clastogenic test compounds as well as for increased sensitivity as compared to traditional Micronucleus Assay only. The test is used for in vitro toxicological risk assessment of chemicals, pesticides, cosmetics, plant extracts, water.

Characteristics

Telomere and Centromere staining allow the identification of aneugenic (telomere and centromere signals) or clastogenic (only telomere signals) compounds.
Improvement of the MNT technique compared to uniform staining (Giemsa, DAPI)
The test can be performed in primary human peripheral blood lymphocytes (HPBLs) or in TK6 cells, translocation of the test system to other cell lines is also offered.
Increased visible effects of clastogenic and aneugenic compounds at low doses
Reduction of MNT baseline in circulating lympocytes of heathy donors

Also available

Service Analytics under GLP and non GLP conditions, please contact info@xenometrix.ch