XenoSkin H - 5 mm Discs - Ex vivo dermatomed Skin Explants for in vitro Dermal Absorption, Skin Permeation, Skin Penetration Tests acc. OECD 428, EU Regulation 2017/745

Art. No.: H-D20D-5

5mm Ø Disks - Frozen Dermatomed Human Abdominal XenoSkin H

Product Description
Documents (2)

XenoSkin H is an ex vivo dermatomed human skin disc for in vitro skin permeation tests, skin absorption or penetration safety studies of chemicals, agrochemicals, pharmaceuticals, cosmetics or biocides and pesticides. The discs are used according to OECD 428, OECD 28, COLIPA, SCCP. XenoSkin H are also used for selecting drug candidates for dermal application, characterization of topical dosage forms, quality assessment, selecting a suitable transdermal vehicle. XenoSkin H is an excellent in vitro model for skin absorption studies and is replacing test animals.

Characteristics for in vitro dermal Permeation Testing

abdominal or face ex vivo skin
average age donor 45 years
aproved for absence of HBV, HCV, HIV-1, HIV-2
time form surgery to lab < 1.5 hours
macroscopic examination for absence of scars, surgical markers or pubic hairs
mean thickness 400 - 600 µm
in line with 3Rs (Reduce, Refine, Replace), replacing animal tests
many different sizes available
Analytical services for in vitro dermal permeation testing is available under GLP according to OECD 428, MDR 2017/745, EFSA, EMA