XenoSkin H Discs - Ex vivo dermatomed Skin Explants for in vitro Dermal Absorption, Permeation and Skin Penetration Tests, OECD 428, EU Reg. 2017/745

Art. No.: H-D20D-10

10mm Ø Disks - Frozen Dermatomed Human Abdominal XenoSkin H

Product Description
Documents (2)

XenoSkin H is an ex vivo dermatomed human skin explant in a disc form for in vitro dermal permeation tests, skin absorption or penetration safety studies of chemicals, agrochemicals, topically applied pharmaceuticals, cosmetics, biocides, pesticides. The skin explants are also used as in vitro method for the evaluation of the barrier properties of medical devices for cutaneous use according Regulation 2017/745, Rule 21. The discs can be used for the safety assessment according to OECD 428, EFSA, EMA, FDA guidelines.

XenoSkin H discs and porcine mucosas are excellent in vitro models for selecting drug candidates for dermal application, characterization of topical dosage forms, quality and safety assessment, selecting a suitable transdermal vehicle. XenoSkin H explants are replacing test animals.

Characteristics for in vitro dermal Permeation Testing

abdominal or face ex vivo skin
average age donor 45 years
aproved for absence of HBV, HCV, HIV-1, HIV-2
time form surgery to lab < 6 hours
macroscopic examination for absence of scars, surgical markers or pubic hairs
mean thickness 400 - 600 µm
in line with 3Rs (Reduce, Refine, Replace), replacing animal tests
many different sizes available
in line with OECD 428, EU Regulation 2017/745, Rule 21 for classification of medical devices, EFSA, EMA and FDA guidelines
Penetration study services available on skin explants or on 3D organotypic tissue models (skin, oral, vaginal, corneal, bladder, colorectal, nasal, intestinal tissues), please contact info@xenometrix.ch

Other ex vivo skin explants and IVPT services