Ames II
- Gee P, Maron DM, Ames BN. 1994. Detection and classification of mutagens: A set of base-specific Salmonella tester strains. PNAS USA. 91(24):11606–10.
- Gee P, Sommers CH, Melick AS, Gidrol XM, Todd MD, Burris RB, Nelson ME, Klemm RC, Zeiger E. 1998. Comparison of responses of base-specific Salmonella tester strains with the traditional strains for identifying mutagens: The results of a validation study. Mutat Res. 412(2):115–30.
Chemicals
- Christen S, Gee P, Ames BN. 1996. Mutagenicity of nitric oxide in base pair-specific Salmonella tester strains: TA7000 series. Methods Enzymol. 269:267–78.
- Chung K-T, Hughes TH, Claxton LD. 2000. Comparison of the mutagenic specificity induced by four nitro-group-containing aromatic amines in Salmonella typhimurium his genes. Mutat Res. 465(1–2):165–71.
- Cornwell DG, Williams MV, Wani AA, Wani G, Shen E, Jones KH. 2002. Mutagenicity of tocopheryl quinones: evolutionary advantage of selective accumulation of dietary a-tocopherol. Nutr Cancer. 43:111–8.
- Dhanju S, Upadhyaya K, Rice CA, Pegan SD, Media J, Valeriote FA, Crich D. 2020. Synthesis, cytotoxicity, and genotoxicity of 10-aza-9-oxakalkitoxin, an N,N,O-trisubstituted hydroxylamine analog, or hydroxalog, of a marine natural product. J Am Chem Soc. 142(20):9147–51.
- Flückiger-Isler S, Baumeister M, Braun K, Gervais V, Hasler-Nguyen N, Reimann R, Van Gompel J, Wunderlich H-G, Engelhardt G. 2004. Assessment of the performance of the Ames II™ assay: A collaborative study with 19 coded compounds. Mutat Res. 558(1–2):181–97.
- Kamber M, Flückiger-Isler S, Engelhardt G, Jaeckh R, Zeiger E. 2009. Comparison of the Ames II and traditional Ames test responses with respect to mutagenicity, strain specificities, need for metabolism and correlation with rodent carcinogenicity. Mutagenesis. 24(4):359–66.
- Keith JM, Jones W, Pierce JM, Seierstad M, Palmer JA, Webb M, Karbarz M, Scott BP, Wilson SJ, Luo L, Wennerholm M, Chang L, Rizzolio M, Rynberg R, Chaplan S, Breitenbucher JG. 2020. Heteroarylureas with fused bicyclic diamine cores as inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett. 30(20):127463.
- Modrzyński JJ, Christensen JH, Brandt KK. 2019. Evaluation of dimethyl sulfoxide (DMSO) as a co-solvent for toxicity testing of hydrophobic organic compounds. Ecotoxicology. 28:1136–41.
- Murata-Kamiya N, Kaji H, Kasai H. 1997. Types of mutations induced by glyoxal, a major oxidative DNA-damage product, in Salmonella typhimurium. Mutat Res. 377(1):13–6.
- Schrader TJ, Langlois I, Soper K, Cherry W. 2002. Mutagenicity of bisphenol A (4,4′‐isopropylidenediphenol) in vitro: effects of nitrosylation. Teratogenesis Carcinog Mutagen. 22:425–41.
Drugs
- Ali W, Więcek M, Łażewska D, Kurczab R, Jastrzębska-Więsek M, Satała G, Kucwaj-Brysz K, Lubelska A, Głuch-Lutwin M, Mordyl B, Siwek A, Nasim MJ, Partyka A, Sudoł S, Latacz G, Wesołowska A, Kieć-Kononowicz K, Handzlik J. 2019. Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT6. Eur J Med Chem. 178:740–51.
- Bach J, Eastwood P, González J, Gómez E, Alonso JA, Fonquerna S, Lozoya E, Orellana A, Maldonado M, Calaf E, Albertí J, Pérez J, Andrés A, Prats N, Carreño C, Calama E, De Alba J, Calbet M, Miralpeix M, Ramis I. 2019. Identification of 2-imidazopyridine and 2-aminopyridone purinones as potent Pan-Janus Kinase (JAK) inhibitors for the inhaled treatment of respiratory diseases. J Med Chem. 62(20):9045–62.
- Baidya SK, Banerjee S, Adhikari N, Jha T. 2022. Selective inhibitors of medium-size S1′ pocket matrix metalloproteinases: A stepping stone of future drug discovery. J Med Chem.
- Emmerich J, van Koppen CJ, Burkhart JL, Hu Q, Siebenbürger L, Boerger C, Scheuer C, Laschke MW, Menger MD, Hartmann RW. 2017. Lead optimization generates CYP11B1 inhibitors of pyridylmethyl isoxazole type with improved pharmacological profile for the treatment of Cushing’s disease. J Med Chem. 60(12):5086–98.
- Hardouin C, Pin F, Giffard J-F, Hervouet Y, Hublet J, Janvier S, Penloup C, Picard J, Pinault N, Schiavi B, Zhang P, Zhao W, Zhu X. 2019. Large scale synthesis of an ampakine-type API based on a telescoped regioselective double amidation reaction. Org Process Res Dev. 23(9):1932–47.
- Kirf D, Higginbotham CL, Rowan NJ, Devery SM. 2010. Cyto- and genotoxicological assessment and functional characterization of N-vinyl-2-pyrrolidone–acrylic acid-based copolymeric hydrogels with potential for future use in wound healing applications. Biomed Mater. 5(3):35002.
- Kuduk SD, DeRatt LG, Stoops B, Shaffer P, Lam AM, Espiritu C, Vogel R, Lau V, Flores OA, Hartman GD
- . Diazepinone HBV Capsid Assembly Modulators. Bioorg Med Chem Lett. 128823
- Papa P, Whitefield B, Mortensen DS, Cashion D, Huang D, Torres E, Parnes J, Sapienza J, Hansen J, Correa M, Delgado M, Harris R, Hegde S, Norris S, Bahmanyar S, Plantevin-Krenitsky V, Liu Z, Leftheris K, Kulkarni A, Bennett B, Hur EM, Ringheim G, Khambatta G, Chan H, Muir J, Blease K, Burnett K, LeBrun L, Morrison L, Celeridad M, Khattri R, Cathers BE. Discovery of the Selective Protein Kinase C‐θ Kinase Inhibitor, CC-90005. J Med Chem. 64:11886–903.
- Rombouts FJR, Kusakabe K-I, Alexander R, Austin N, Borghys H, De Cleyn M, Dhuyvetter D, Gijsen HJM, Hrupka B, Jacobs T, Jerhaoui S, Lammens L, Leclercq L, Tsubone K, Ueno T, Morimoto K, Einaru S, Sumiyoshi H, Van den Bergh A, Vos A, Surkyn M, Teisman A, Moechars D. 2021. JNJ-67569762, A 2‑Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate. J Med Chem. 64(19):14175–91.
- Wang Y-X, Zhao L, Nagashima M, Vincelette J, Sukovich D, Li W, Subramanyam B, Yuan S, Emayan K, Islam I, Hrvatin P, Bryant J, Light DR, Vergona R, Morser J, Buckman BO. 2007. A novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) – Part I: Pharmacological characterization. Thromb Haemost. 97(1):47–53.
- Xu G, Gaul MD, Kuo G-H, Du F, Xu JZ, Wallace N, Hinke S, Kirchner T, Silva J, Huebert ND, Lee S, Murray W, Liang Y, Demarest K. 2018. Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors. Bioorg Med Chem Lett. 28(21):3446–53.
Environmental Samples
- Erdinger L, Dörr I, Dürr M, Höpker K-A. 2004. Analysis of mutagenic activity of airborne particulate matter, standard reference materials and reference compounds using base pair-specific Salmonella typhimurium tester strains. Mutat Res. 564(2):149–57.
- Miller AC, Fuciarelli AF, Jackson WE, Ejnik EJ, Emond C, Strocko S, Hogan J, Page N, Pellmar T. 1998. Urinary and serum mutagenicity studies with rats implanted with depleted uranium or tantalum pellets. Mutagenesis. 13(6):643–8.
- Van Den Heuvel R, Staelens J, Koppen G, Schoeters G. 2018. Toxicity of urban PM10 and relation with tracers of biomass burning. Int J Environ Res Public Health. 15(2):320.
Water Samples
- Abdelsamie AS, van Koppen CJ, Bey E, Salah M, Börger C, Siebenbürger L, Laschke MW, Menger MD, Frotscher M. 2017. Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC50 for a proof-of-principle study. Eur J Med Chem. 127:944–57.
- Brienza M, Manasfi R, Chiron S. 2019. Relevance of N-nitrosation reactions for secondary amines in nitrate-rich wastewater under UV-C treatment. Eur J Med Chem. 162:22–9.
- Heringa MB, Harmsen DJH, Beerendonk EF, Reus AA, Krul CAM, Metz DH, Ijpelaar GF. 2011. Formation and removal of genotoxic activity during UV/H2O2–GAC treatment of drinking water. Water Res. 45(1):366–74.
- Hull NM, Rosenblum JS, Robertson CE, Harris JK, Linden KG. 2018. Succession of toxicity and microbiota in hydraulic fracturing flowback and produced water in the Denver–Julesburg Basin. Sci Tot Env. 644:183–92.
- Kolkman A, Schriks M, Brand W, Bäuerlein PS, van der Kooi MM, van Doorn RH, Emke E, Reus AA, van der Linden SC, de Voogt P, Heringa MB. 2013. Sample preparation for combined chemical analysis and in vitro bioassay application in water quality assessment. Environ Toxicol Pharmacol. 36(3):1291–303.
- Martijn BJ, Van Rompay AR, Penders EJM, Alharbi Y, Baggelaar PK, Kruithof JC, Rietjens IMCM. 2016. Development of a 4-NQO toxic equivalency factor (TEF) approach to enable a preliminary risk assessment of unknown genotoxic compounds detected by the Ames II test in UV/H2O2 water treatment samples. Chemosphere. 144:338–45.
- Mestankova H, Schirmer K, Canonica S, von Gunten U. 2014. Development of mutagenicity during degradation of N-nitrosamines by advanced oxidation processes. Water Res. 66:399–410.
- Ozores Diez P, Giannakis S, Rodríguez-Chueca J, Wang D, Quilty B, Devery R, McGuigan K, Pulgarin C. 2020. Enhancing solar disinfection (SODIS) with the photo-Fenton or the Fe2+/peroxymonosulfate-activation process in large-scale plastic bottles leads to toxicologically safe drinking water. Water Res. 186:116387.
- Ozores Diez P, Polo-López MI, Martínez-García A, Waso M, Reyneke B, Khan W, McGuigan KG, Fernández-Ibáñez P, Devery R, Quilty B. 2021. In vitro toxicity studies of novel solar water disinfection reactors using the E-screen bioassay and the Ames test. H2O Open Journal. 4(1):204–15.
- Parker AM, Lester Y, Spangler EK, von Gunten U, Linden KG. 2017. UV/H2O2 advanced oxidation for abatement of organophosphorous pesticides and the effects on various toxicity screening assays. Chemosphere. 182:477–482.
- Semitsoglou-Tsiapou S, Templeton MR, Graham NJD, Mandal S, Hernández Leal L, Kruithof JC. 2018. Potential formation of mutagenicity by low pressure-UV/H2O2 during the treatment of nitrate-rich source waters. Environ Sci: Water Res Technol. 4:1252–61.
Extracts
- Chandrasekaran CV, Thiyagarajan P, Sundarajan K, Goudar KS, Deepak M, Murali B, Allan JJ, Agarwal A. 2009. Evaluation of the genotoxic potential and acute oral toxicity of standardized extract of Andrographis paniculata (KalmCold™). Food Chem Toxicol. 47(8):1892–902.
- Chandrasekaran CV, Sundarajan K, David K, Agarwal A. 2010. In vitro efficacy and safety of poly-herbal formulations. Toxicol In Vitro. 24(3):885–97.
- Chandrasekaran CV, Sundarajan K, Gupta A, Srikanth HS, Edwin J, Agarwal A. 2011. Evaluation of the genotoxic potential of standardized extract of Glycyrrhiza glabra (GutGard™). Regul Toxicol Pharmacol. 61(3):373–80.
Passive Dosing Vs. Solvent Spiking
- Smith KEC, Heringa MB, Uytewaal M, Mayer P. 2013. The dosing determines mutagenicity of hydrophobic compounds in the Ames II assay with metabolic transformation: Passive dosing versus solvent spiking. Mutat Res. 750(1–2):12–8.
Statistical Analyses
- Piegorsch WW, Simmons SJ, Margolin BH, Zeiger E, Gidrol XM, Gee P. 2000. Statistical modeling and analyses of a base-specific Salmonella mutagenicity assay. Mutat Res. 467(1):11–9.