Chemicals
- Spiliotopoulos D, Koelbert C, Audebert M, Barisch I, Bellet D, Constans M, Czich A, Finot F, Gervais V, Khoury L, Kirchnawy C, Kitamoto S, Le Tesson A, Malesic L, Matsuyama R, Mayrhofer E, Mouche I, Preikschat B, Prielinger L, Rainer B, Roblin C, Wäse K. 2024. Assessment of the performance of the Ames MPF™ assay: A multicenter collaborative study with six coded chemicals. Mutat Res Genet Toxicol Environ Mutagen. 893:503718
- Klaudia Szymczak, Grzegorz Szewczyk, Michał Rychłowski, Tadeusz Sarna, Lei Zhang, Mariusz Grinholc, and Joanna Nakonieczna. 2023. Photoactivated Gallium Porphyrin Reduces Staphylococcus aureus Colonization on the Skin and Suppresses Its Ability to Produce Enterotoxin C and TSST-1 Mol. Pharmaceutics.
- Adebola O, Corcoran O, Morgan WA. 2013. Protective effects of prebiotics inulin and lactulose from cytotoxicity and genotoxicity in human colon adenocarcinoma cells. Food Res Intl. 52(1):269–74.
- Borowik A, Prylutskyy Y, Kawelski Ł, Kyzyma O, Bulavin L, Ivankov O, Cherepanov V, Wyrzykowski D, Kaźmierkiewicz R, Gołuński G, Woziwodzka A, Evstigneev M, Ritter U, Piosik J. 2018. Does C60 fullerene act as a transporter of small aromatic molecules?. Colloids Surf B Biointerfaces. 164:134–43.
- Chao M-W, Tseng C-Y, Lin P-Y, Chang Y-J, Köse Ö, Sabuncuoğlu S, Chen Y-C, Lin C-H, Kocer-Gumusel B, Erkekoğlu P. 1998. 3,5-Dimethylaminophenol is not mutagenic in Ames test and HPRT test and may have anti-carcinogenic potential against lung cancer cells. Proceedings. 2(25):1553.
- Claxton LD, Hughes TJ, Chung KT. 2001. Using base-specific Salmonella tester strains to characterize the types of mutation induced by benzidine and benzidine congeners after reductive metabolism. Food Chem Toxicol. 39(12):1253–61.
- Erkekoğlu P, Chao M-W, Kose O, Sabuncuoğlu S, Kocer-Gumusel B. 2017. The mutagenic potential of 3,5-dimethylaminophenol in bacterial and mammalian cells. FABAD J Pharm Sci. 42(2):87-93.
- Gołuński G, Woziwodzka A, Iermak I, Rychłowski M, Piosik J. 2013. Modulation of acridine mutagen ICR191 intercalation to DNA by methylxanthines – Analysis with mathematical models. Bioorg Med Chem. 21(11):3280–9.
- Jin S, Byrne FP, Clark JH, McElroy CR, Quinn A, Sherwood J, Hunt AJ. 2021. 3-Methoxybutan-2-one as a sustainable bio-based alternative to chlorinated solvents. RSC Adv. 11:39412–9.
- Musial J, Krakowiak R, Frankowski R, Spychala M, Dlugaszewska J, Dobosz B, Bendzinska-Berus W, Krzyminiewski R, Tykarska E, Zgoła-Grześkowiak A, Goslinski T, Mlynarczyk DT, Stanisz BJ. 2022. Simple modification of titanium(IV) oxide for the preparation of a reusable photocatalyst. Materials Sci Eng: B. 276:115559.
- Prylutskyy Y, Borowik A, Gołuński G, Woziwodzka A, Piosik J, Kyzyma O, Pashkova I, Ritter U, Evstigneev M. 2016. Biophysical characterization of the complexation of C60 fullerene with doxorubicin in a prokaryotic model. Mat-wiss u Werkstofftech. 47:2–3.
- Regulska K, Murias M, Stanisz B, Regulski M. 2014. The mutagenicity analysis of imidapril hydrochloride and its degradant, diketopiperazine derivative, nitrosation mixtures by in vitro Ames test with two strains of Salmonella typhimurium. Rep Pract Oncol Radiother. 19(6):412–9.
- Reifferscheid G, Maes HM, Allner B, Badurova J, Belkin S, Bluhm K, Brauer F, Bressling J, Domeneghetti S, Elad T, Flückiger-Isler S, Grummt HJ, Gürtler R, Hecht A, Heringa MB, Hollert H, Huber S, Kramer M, Magdeburg A, Ratte HT, Sauerborn-Klobucar R, Sokolowski A, Soldan P, Smital T, Stalter D, Venier P, Ziemann C, Zipperle J, Buchinger S. 2012. International round‐robin study on the Ames fluctuation test. Environ Mol Mutagen. 53(3):185–97.
- Sieroslawska A. 2013. Assessment of the mutagenic potential of cyanobacterial extracts and pure cyanotoxins. 74:1-7.
- Williams et al. 2011. Toxicologic characterization of a novel explosive, triaminoguanidinium-1-methyl-5-nitriminotetrazolate (TAG-MNT), in female rats and in vitro assays. J Toxicol Environ Health Sci. 3(3):80–94.
Comparison with the Ames Test in Petri Dishes
- Flueckiger-Isler S, Kamber M. 2012. Direct comparison of the Ames microplate format (MPF) test in liquid medium with the standard Ames pre-incubation assay on agar plates by use of equivocal to weakly positive test compounds. Mutat Res. 747(1):36–45.
- Kim MJ, Heo S, Nam S, Back S-M, Park SH, Oh JJ, Chung Y-S. 2021. Reverse Mutation Evaluation for Eight Chemicals using Microplate Method. Journal of Alternatives to Animal Experiments. 15(1):45–55. [in Korean]
- Spiliotopoulos D, Koelbert C. 2020. Assessment of the miniaturized liquid Ames microplate format (MPF™) for a selection of the test items from the recommended list of genotoxic and non-genotoxic chemicals. Mutat Res. 856–857:503218.
- Rainer B, Pinter E, Prielinger L, Coppola C, Marin-Kuan M, Schilter B, Apprich S, Tacker M. 2021. Direct comparison of the lowest effect concentrations of mutagenic reference substances in two Ames test formats. Toxics. 9(7):152.
(Bio)Polymers
- Bandyopadhyay-Ghosh S, Ghosh SB, Rodriguez A, Sain MM. 2017. Biosynthesis, microstructural characterisations and investigation of in-vitro mutagenic and eco-toxicological response of a novel microbial exopolysaccharide based biopolymer. J Polym Environ. 26(1):365–74.
- Harvey BG, Yandek GR, Lamb JT, Eck WS, Garrison MD, Davis MC. 2017. Synthesis and characterization of a high temperature thermosetting polyimide oligomer derived from a non-toxic, sustainable bisaniline. RSC Adv. 37:23149–56.
Drugs
- Ahn J, Ko D, Yang S, Moon KH, Woo J, Yoo H, Ahn J, Lee JH, Chung KS, Lee K-T, Lee JY. 2021. Chiral Resolution, Absolute Configuration Assignment, and Genotoxicity Evaluation of Racemic 3,4-Dihydroquinazoline as a Novel Anticancer Agent. J Chem. 6169055.
- Altıntop MD, Özdemir A, Turan-Zitouni G, Ilgın S, Atlı Ö, İşcan G, Kaplancıklı ZA. 2012. Synthesis and biological evaluation of some hydrazone derivatives as new anticandidal and anticancer agents. Eur J Med Chem. 58:299–307.
- Altıntop MD, Özdemir A, Turan-Zitouni G, Ilgın S, Atlı Ö, Demirel R, Kaplancıklı ZA. 2015. A novel series of thiazolyl–pyrazoline derivatives: Synthesis and evaluation of antifungal activity, cytotoxicity and genotoxicity. Eur J Med Chem. 92:342–52.
- Altıntop MD, Atlı Ö, Ilgın S, Demirel R, Özdemir A, Kaplancıklı ZA. 2016. Synthesis and biological evaluation of new naphthalene substituted thiosemicarbazone derivatives as potent antifungal and anticancer agents. Eur J Med Chem. 108:406–14.
- Al-Serori H, Ferk F, Angerer V, Mišík M, Nersesyan A, Setayesh T, Auwärter V, Haslinger E, Huber W, Knasmüller S. 2016. Investigations of the genotoxic properties of twosynthetic cathinones (3-MMC, 4-MEC) which are used as psychoactive drugs. Toxicol Res. 5:1410–20.
- Bach J, Eastwood P, González J, Gómez E, Alonso JA, Fonquerna S, Lozoya E, Orellana A, Maldonado M, Calaf E, Albertí J, Pérez J, Andrés A, Prats N, Carreño C, Calama E, De Alba J, Calbet M, Miralpeix M, Ramis I. 2019. Identification of 2-imidazopyridine and 2-aminopyridone purinones as potent Pan-Janus Kinase (JAK) inhibitors for the inhaled treatment of respiratory diseases. J Med Chem. 62(20):9045–60. [also Ames II]
- Basu S, Middya S, Banerjee M, Ghosh R, Pryde DC, Yadav DB, Shrivastava R, Surya A. 2021. The discovery of potent small molecule cyclic urea activators of STING. Eur J Med Chem. 114087.
- Benes P, Alexova P, Knopfova L, Spanova A, Smarda J. 2012. Redox state alters anti‐cancer effects of wedelolactone. Environ Mol Mutagen. 53(7):515–24.
- Blum L, Gul S, Ulshöfer T, Henke M, Krieg R, Berneburg I, Thomas D, Trautmann S, Kurz J, Geyer J, Geisslinger G, Becker K, Parnham MJ, Schiffmann S. 2020. In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o. Sci Rep. 10:7534.
- Buzun K, Gornowicz A, Lesyk R, Kryshchyshyn-Dylevych A, Gzella A, Czarnomysy R, Latacz G, Olejarz-Maciej A, Handzlik J, Bielawski K, Bielawska A. 2022. 2-{5-[(Z,2Z)-2-Chloro-3-(4-nitrophenyl)-2-propenylidene]-4-oxo-2-thioxothiazolidin-3-yl}-3-methylbutanoic Acid as a Potential Anti-Breast Cancer Molecule. Int J Mol Sci. 23(8):4091.
- Bhawna, Kumar A, Bhatia M, Kapoor A, Kumar P, Kumar S. 2022. Monoamine oxidase inhibitors: A concise review with special emphasis on structure activity relationship studies. Eur J Med Chem.
- Can NÖ, Osmaniye D, Levent S, Sağlık BN, Korkut B, Atlı Ö, Özkay Y, Kaplancıklı ZA. 2017. Design, synthesis and biological assessment of new thiazolylhydrazine derivatives as selective and reversible hMAO-A inhibitors. Eur J Med Chem. 144:68–81.
- Cardoso HS, Bicalho B, Genaria P, Santagada V, Caliendo G, Perissutti E, Donato JL, De Nucci G. 2006. In vitro mutagenicity of anti-inflammatory parsalmide analogues PA7, PA10, and PA31 triggered by biotransformation into hydroxy derivatives. Eur J Med Chem. 41(3):408–16.
- Dąbrowska-Maś E, Raś W. 2017. Metronidazole citrate ester as the new prodrug of metronidazole. Curr Chem Lett. 6(4):167–76.
- Domaradzka D, Guzik U, Hupert-Kocurek K, Wojcieszyńska D. 2016. Toxicity of diclofenac and its biotransformation by Raoultella DD4. Pol J Environ Stud. 25(5):2211–6.
- Erguc A, Altintop, MD, Atli O, Sever, B, Iscan, G, Gormus, G, Ozdemir, A. 2018. Synthesis and biological evaluation of new quinoline-based thiazolyl hydrazone derivatives as potent antifungal and anticancer agents. Lett Drug Des Discov. 15(2):193–202.
- Ferk F, Gminski R, Al-Serori H, Mišík M, Nersesyan A, Koller VJ, Angerer V, Auwärter V, Tang T, Arif AT, Knasmüller S. 2016. Genotoxic properties of XLR-11, a widely consumed synthetic cannabinoid, and of the benzoyl indole RCS-4. Arch Toxicol. 90(12):3111–23.
- Gołuński G, Borowik A, Lipińska A, Romanik M, Derewońko N, Woziwodzka A, Piosik J. 2016. Pentoxifylline affects idarubicin binding to DNA. Bioorg Chem. 65:118–25.
- Gołuński G, Borowik A, Derewońko N, Kawiak A, Rychłowski M, Woziwodzka A, Piosik J. 2016. Pentoxifylline as a modulator of anticancer drug doxorubicin. Part II: Reduction of doxorubicin DNA binding and alleviation of its biological effects. Biochimie. 123:95–102.
- Górny D, Guzik U, Hupert-Kocurek K, Wojcieszyńska D. 2019. Naproxen ecotoxicity and biodegradation by Bacillus thuringiensis B1(2015b) strain. Ecotoxicol Environ Safety. 167:505–12.
- Gyimesi M, Horváth ÁI, Túrós D, Suthar SK, Pénzes M, Kurdi C, Canon L, Kikuti C, Ruppel KM, Trivedi DV, Spudich JA, Lőrincz I, Rauscher AÁ, Kovács M, Pál E, Komoly S, Houdusse A, Málnási-Csizmadia A. 2020. Single residue variation in skeletal muscle myosin enables direct and selective drug targeting for spasticity and muscle stiffness. Cell. 183(2):335–346.e13.
- Hawryluk N, Robinson D, Shen Y, Kyne G, Bedore M, Menon S, Canan S, von Geldern T, Townson S, Gokool S, Ehrens A, Koschel M, Lhermitte-Vallarino N, Martin C, Hoerauf A, Hernandez G, Dalvie D, Specht S, Hübner MP, Scandale I. 2022. Discovery of substituted di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as novel macrofilaricidal compounds for the treatment of human filarial infections. J Med Chem.
- Itzhanova KI, Seidakhmetova RB, Adekenov SM. 2018. Investigation of the mutagenic potential of immunomodulator arglabin native in tablets in the Ames test. J Pharm Pharmacol. 6:790–5.
- Janetka JW, Hopper AT, Yang Z, Barks J, Dhason MS, Wang Q, Sibley LD. 2020. Optimizing pyrazolopyrimidine inhibitors of calcium dependent protein kinase 1 for treatment of acute and chronic toxoplasmosis. J Med Chem. 63(11):6144–63.
- Karaman N, Zainel RA, Kapkaç HA, Gençer HK, Ilgın S, Karaduman AB, Karaküçük-İyidoğan A, Oruç-Emre EE, Koçyiğit-Kaymakçıoğlu B. 2018. Design and evaluation of biological activities of 1,3‐oxazolidinone derivatives bearing amide, sulfonamide, and thiourea moieties. Arch Pharm DPhG. 351(9):790–5.
- Karayildirim ÇK, Kotmakçi M, Halay E, Ayd K, Başpinar Y. 2018. Formulation, characterization, cytotoxicity and Salmonella/microsome mutagenicity (Ames) studies of a novel 5-fluorouracil derivative. Saudi Pharm J. 26(3):369–74.
- Kim WC, Kang J-A, Park M, Jeong P-H, Kim YJ, Cho Z, Park S-G, Kim Y-C. 2021. Discovery of novel pyrimidine-based capsid assembly modulators as potent anti-HBV agents. J Med Chem. 64(9):5500–18.
- Koller VJ, Auwärter V, Grummt T, Moosmann B, Mišík M, Knasmüller S. 2014. Investigation of the in vitro toxicological properties of the synthetic cannabimimetic drug CP-47,497-C8. Toxicol Appl Pharmacol. 277:164–71.
- Koller VJ, Ferk F, Al-Serori H, Mišík M, Nersesyan A, Auwärter V, Grummt T, Knasmüller S. 2015. Genotoxic properties of representatives of alkylindazoles and aminoalkyl-indoles which are consumed as synthetic cannabinoids. Food Chem Toxicol. 80:130–6.
- Mulla MS, Vedamurthy RB, Jana S, Pandey SK, Goyal VK, Nirogi R. 2012. Mutagenicity and clastogenicity evaluation of tacrine by Ames and micronucleus assays. Drug Chem Toxicol. 35(4):366–70.
- Ovonramwen OB, Owolabi BJ, Oviawe AP. 2019. Recent advances in chalcones: Synthesis, transformation and pharmacological activities. As J Chem Sci. 6(3):1–16.
- Oztas E, Ulus B, Özhan G. 2015. In vitro investigation on the toxic potentials of commonly used synthetic pyrethroids, especially esbiothrin. Appl In Vitro Toxicol. 1(4):302–7.
- Ramires PA, Miccoli MA, Panzarini E, Dini L, Protopapa C. 2005. In vitro and in vivo biocompatibility evaluation of a polyalkylimide hydrogel for soft tissue augmentation. J Biomed Mater Res B Appl Biomater. 72(2):230–8.
- Ranganatha R, Chakravarthy S, Sukumaran SK. 2015. High-throughput approaches for genotoxicity testing in drug development: recent advances. Int J High Throughput Screen. 6:1–12. [review]
- Schiffmann S, Gunne S, Ulshöfer T, Henke M, Roser LA, Schneider A-K, Cinatl J, Thomas D, Schreiber Y, Wagner PV, Grünweller A, Parnham MJ. 2022. In vitro safety, off-target and bioavailability profile of the antiviral compound silvestrol. Pharmaceuticals. 15:1086.
- Stankiewicz A, Kaczorowska K, Bugno R, Kozioł A, Paluchowska MH, Burnat G, Chruścicka B, Chorobik P, Brański P, Wierońska JM, Duszyńska B, Pilc A, Bojarski AJ. 2022. New 1,2,4-oxadiazole derivatives with positive mGlu4 receptor modulation activity and antipsychotic-like properties. J Enzyme Inhib Med Chem. 37(1):211–25.
- Witek K, Nasim MJ, Bischoff M, Gaupp R, Arsenyan P, Vasiljeva J, Marć MA, Olejarz A, Latacz G, Kieć-Kononowicz K, Handzlik J, Jacob C. 2017. Selenazolinium salts as “small molecule catalysts” with high potency against ESKAPE bacterial pathogens. Molecules. 22(12):2174.
- Zhanataev AK, Borovskaya TG, Shcherbakova BS, Rudoi BA, Vychuzhanina AV, Grigor'eva VA, Kamalova SI, Durnev AD. 2019. Evaluation of Kagocel Genotoxicity. Bull Exp Biol Med. 166(6):731–4.
- Żur J, Wojcieszyńska D, Hupert-Kocurek K, Marchlewicz A, Guzik U. 2018. Paracetamol – Toxicity and microbial utilization. Pseudomonas moorei KB4 as a case study for exploring degradation pathway. Chemosphere. 206:192–202.
Impurities
- Emerce E, Cok I, Degim IT. 2015. Determination of the impurities in drug products containing montelukast and in silico/in vitro genotoxicological assessments of sulfoxide impurity. Toxicol Lett. 238(2): 90–9.
- Emerce E, Cok I, Sari S, Bostanci O. 2016. An investigation of the mutagenic activity of salamide – a major impurity of hydrochlorothiazide. Toxicol Mech Methods. 26(9):644–9.
Antimicrobial Agents
- Altıntop MD, Özdemir A, Atlı Ö, Cantürk Z, Baysal M, Kaplancıklı ZA. 2016. Synthesis and evaluation of new thiazole derivatives as potential antimicrobial agents. Lett Drug Des Discov. 13(9):903–11.
- Altintop MD, Sever B, Eklioğlu ÖA, Baysal M, Demirel R, Özdemir A. 2020. A series of furan-based hydrazones: Design, synthesis, and evaluation of antimicrobial activity, cytotoxicity and genotoxicity. Lett Drug Des Discov. 17(3):312–22(11).
- Nesterenko LN, Zigangirova NA, Zayakin ES, Luyksaar SI, Kobets NV, Balunets DV, Shabalina LA, Bolshakova TN, Dobrynina OY, Gintsburg AL. 2016. A small-molecule compound belonging to a class of 2,4-disubstituted 1,3,4-thiadiazine-5-ones suppresses Salmonella infection in vivo. J Antibiot (Tokyo). 69(6):422–7.
- Toolaram AP, Haddad T, Leder C, Kümmerer K. 2016. Initial hazard screening for genotoxicity of photo-transformation products of ciprofloxacin by applying a combination of experimental and in-silico testing. Environ Pollut. 211:148–56.
Histamine Receptors Modulators
- Alachkar A, Latacz G, Siwek A, Lubelska A, Honkisz E, Gryboś A, Łażewska D, Handzlik J, Stark H, Kiec-Kononowicz K, Sadek B. 2018. Anticonvulsant evaluation of novel non-imidazole histamine H3R antagonists in different convulsion models in rats. Pharmacol Biochem Behav. 170:14–24.
- Łażewska D, Kaleta M, Hagenow S, Mogilski S, Latacz G, Karcz T, Lubelska A, Honkisz E, Handzlik J, Reiner D, Satała G, Filipek B, Stark H, Kieć-Kononowicz K. 2018. Novel naphthyloxy derivatives – Potent histamine H3 receptor ligands. Synthesis and pharmacological evaluation. Bioorg Med Chem. 26(9):2573–85.
Serotonin Receptors Modulators
- Drop M, Canale V, Chaumont-Dubel S, Kurczab R, Satała G, Bantreil X, Walczak M, Koczurkiewicz-Adamczyk P, Latacz G, Gwizdak A, Krawczyk M, Gołębiowska J, Grychowska K, Bojarski AJ, Nikiforuk A, Subra G, Martinez J, Pawłowski M, Popik P, Marin P, Lamaty F, Zajdel P. 2021. 2-Phenyl-1H-pyrrole-3-carboxamide as a new scaffold for developing 5-HT6 receptor inverse agonists with cognition-enhancing activity. ACS Chem Neurosci. 12(7):1228–40.
- Hogendorf AS, Hogendorf A, Kurczab R, Kalinowska-Tłuścik J, Popik P, Nikiforuk A, Krawczyk M, Satała G, Lenda T, Knutelska J, Bugno R, Staroń J, Pietruś W, Matłoka M, Dubiel K, Moszczyński-Pętkowski R, Pieczykolan J, Wieczorek M, Pilarski B, Zajdel P, Bojarski AJ. 2019. 2-Aminoimidazole-based antagonists of the 5-HT6 receptor – A new concept in aminergic GPCR ligand design. Eur J Med Chem. 179:1–15.
- Latacz G, Lubelska A, Jastrzębska-Więsek M, Partyka A, Sobiło A, Olejarz A, Kucwaj-Brysz K, Satała G, Bojarski AJ, Wesołowska A, Kieć-Kononowicz K, Handzlik J. 2017. In the search for a lead structure among series of potent and selective hydantoin 5‐HT7R agents: The drug‐likeness in vitro study. Chem Biol Drug Des. 90(6):1295–306.
- Latacz G, Lubelska A, Jastrzębska-Więsek M, Partyka A, Kucwaj-Brysz K, Wesołowska A, Kieć-Kononowicz K, Handzlik J. 2018. MF-8, a novel promising arylpiperazine-hydantoin based 5-HT7 receptor antagonist: In vitro drug-likeness studies and in vivo pharmacological evaluation. Bioorg Med Chem Lett. 28(5):878–83.
- Latacz G, Hogendorf AS, Hogendorf A, Lubelska A, Wierońska JM, Woźniak M, Cieślik P, Kieć-Kononowicz K, Handzlik J, Bojarski AJ. 2018. Search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1H-imidazol-5-yl)-1H-indole-5-carboxamides, low-basicity 5-HT7 receptor agonists. Med Chem Comm. 9:1882–90.
- Staroń J, Kurczab R, Warszycki D, Satała G, Krawczyk M, Bugno R, Lenda T, Popik P, Hogendorf AS, Hogendorf A, Dubiel K, Matłoka M, Moszczyński-Pętkowski R, Pieczykolan J, Wieczorek M, Zajdel P, Bojarski AJ. 2020. Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties. Eur J Med Chem. 185:111857.
- Vanda D, Soural M, Canale V, Chaumont-Dubel S, Satała G, Kos T, Funk P, Fülöpová V, Lemrová B, Koczurkiewicz P, Pękala E, Bojarski AJ, Popik P, Marin P, Zajdel P. 2017. Novel non-sulfonamide 5-HT6 receptor partial inverse agonist in a group of imidazo[4,5-b]pyridines with cognition enhancing properties. Eur J Med Chem. 144:716–29.
Environmental Samples
- Chouquet T, Acramel A, Sauvageon H, Plé A, Jourdan N, Madelaine I, Faure P, Mourah S, Goldwirt L. 2018. Mutagenicity assessment of environmental contaminations in a hospital centralized reconstitution unit. Ecotoxicol Env Safety. 165:174–81.
- de Aragão Umbuzeiro G, Rech CM, Correia S, Bergamasco AM, Lima Cardenette GH, Flückiger-Isler S, Kamber M. 2010. Comparison of the Salmonella/microsome microsuspension assay with the new microplate fluctuation protocol for testing the mutagenicity of environmental samples. Environ Mol Mutagen. 51(1):31–8.
- Faber A-H, Brunner AM, Dingemans MML, Baken KA, Kools SAE, Schot PP, de Voogt P, van Wezel AP. 2021. Comparing conventional and green fracturing fluids by chemical characterisation and effect-based screening. Sci Tot Environ. 794:148727.
- Kozłowska A, Olewińska E, Pawlas N. 2012. Microplate Ames MPF test use in assessment of mutagenic properties of dust pollution. Medycyna Środowiskowa. 15(3):55–65.
- Leighfield TA, Muha N, Ramsdell JS. 2009. Brevetoxin B is a clastogen in rats, but lacks mutagenic potential in the SP-98/100 Ames test. Toxicon. 54(6):851–6.
- Mansouri A, Cregut M, Jouanneau S, Thouand G, Durand M-J. 2022. Evaluation of biomonitoring strategies to assess performance of a bioremediation bioprocess. Sustainability. 14(17):10932.
- Rybak J, Wróbel M, Krzyżyńska R, Rogula–Kozłowska W, Olszowski T. 2022. Is Poland at risk of urban road dust? Comparison studies on mutagenicity of dust. Environ Pollut. 314:120337.
- Wieczerzak M, Namieśnik J, Kudłak B. 2016. Bioassays as one of the Green Chemistry tools for assessing environmental quality: A review. Environm Int. 94:341–61. [review]
Water Samples
- Balabanič D, Filipič M, Krivograd Klemenčič A, Žegura B. 2021. Genotoxic activity of endocrine disrupting compounds commonly present in paper mill effluents. Sci Tot Environm. 794:148489.
- Faber A-H, Annevelink MPJA, Schot PP, Baken KA, Schriks M, Emke E, de Voogt P, van Wezel AP. 2019. Chemical and bioassay assessment of waters related to hydraulic fracturing at a tight gas production site. Sci Tot Env. 690:636–46.
- Kienle C, Werner I, Fischer S, Lüthi C, Schifferli A, Besselink H, Langer M, McArdell CS, Vermeirssen ELM. 2022. Evaluation of a full-scale wastewater treatment plant with ozonation and different post-treatments using a broad range of in vitro and in vivo bioassays. Water Res. 212:118084.
- Islas-Espinoza M, de las Heras A, Urban J, Brewer SE, Donkor KK, Rincón E. 2021. CPC artificial solar lysis of bacterial and plasmid DNA in rainwater and snow by UV, VIS, NIR, temperature and pressure. Zenodo. DOI:10.5281/zenodo.4642049.
- Majumdar S, Priyadarshinee R, Kumar A, Mandal T, Mandal DD. 2019. Exploring Planococcus sp. TRC1, a bacterial isolate, for carotenoid pigment production and detoxification of paper mill effluent in immobilized fluidized bed reactor. J Cleaner Prod. 211:1389–402.
- Martijn BJ, Kruithof JC, Hughes RAM, Mastan RA, Van Rompay AR, Malley JP. 2015. Induced genotoxicity in nitrate-rich water treated with medium-pressure ultraviolet processes. AWWA. 107(6):E301–12.
- Menz J, Toolaram AP, Rastogi T, Leder C, Olsson O, Kümmerer K, Schneider M. 2016. Transformation products in the water cycle and the unsolved problem of their proactive assessment: A combined in vitro/in silico approach. Environm Intl. 98:171–80.
- Pérez S, Reifferscheid G, Eichhorn P, Barceló D. 2003. Assessment of the mutagenic potency of sewage sludges contaminated with polycyclic aromatic hydrocarbons by an Ames fluctuation assay. Environ Toxicol Chem. 22(11):2576–84.
- Reifferscheid G, Buchinger S, Cao Z, Claus E. 2011. Identification of mutagens in freshwater sediments by the Ames-fluctuation assay using nitroreductase and acetyltransferase overproducing test strains. Environ Mol Mutagen. 52(5):397–408.
- Reifferscheid G, Maes HM, Allner B, Badurova J, Belkin S, Bluhm K, Brauer F, Bressling J, Domeneghetti S, Elad T, Flückiger-Isler S, Grummt HJ, Gürtler R, Hecht A, Heringa MB, Hollert H, Huber S, Kramer M, Magdeburg A, Ratte HT, Sauerborn-Klobucar R, Sokolowski A, Soldan P, Smital T, Stalter D, Venier P, Ziemann C, Zipperle J, Buchinger S. 2012. International round‐robin study on the Ames fluctuation test. Environ Mol Mutagen. 53(3):185–97.
- Zhang A, Jia A, Park M, Li Y, Snyder SA. 2019. Genotoxicity assay and potential byproduct identification during different UV-based water treatment processes. Chemosphere. 217:176–82.
Fuel-Related Samples
- Agarwal AK, Ateeq B, Gupta T, Singh AP, Pandey SK, Sharma N, Agarwal RA, Gupta NK, Sharma H, Jain A, Shukla PC. 2018. Toxicity and mutagenicity of exhaust from compressed natural gas: Could this be a clean solution for megacities with mixed-traffic conditions?. Environ Pollut. 239:499–511.
- Agarwal AK, Singh AP, Gupta T, Agarwal RA, Sharma N, Rajput P, Pandey SK, Ateeq B. 2018. Mutagenicity and cytotoxicity of particulate matter emitted from biodiesel-fueled engines. Environ Sci Technol. 52(24):499–511.
- Morais Leme D, Grummt T, Heinze R, Sehr A, Renz S, Reinel S, Palma de Oliveira D, Ferraz ERA, Rodrigues de Marchi MR, Canto Machado M, Juliao Zocolo G, Marin-Morales MA. 2012. An overview of biodiesel soil pollution: Data based on cytotoxicity and genotoxicity assessments. J Hazard Mater. 199–200:343–9.
- Morais Leme D, Grummt T, Palma de Oliveira D, Sehr A, Renz S, Reinel S, Ferraz ERA, Rodrigues de Marchi MR, Canto Machado M, Julião Zocolo G, Marin-Morales MA. 2012. Genotoxicity assessment of water soluble fractions of biodiesel and its diesel blends using the Salmonella assay and the in vitro MicroFlow® kit (Litron) assay. Chemosphere. 86(5):512–20.
- Steiner S, Czerwinski J, Comte P, Heeb NV, Mayer A, Petri-Fink A, Rothen-Rutishauser B. 2014. Effects of an iron-based fuel-borne catalyst and a diesel particle filter on exhaust toxicity in lung cells in vitro. Anal Bioanal Chem. 20:5977–86.
- Steiner S, Heeb NV, Czerwinski J, Comte P, Mayer A, Petri-Fink A, Rothen-Rutishauser B. 2014. Test-methods on the test-bench: a comparison of complete exhaust and exhaust particle extracts for genotoxicity/mutagenicity assessment. Environ Sci Technol. 48(9):5237–44.
PAHs
- Gurbani D, Bharti SK, Kumar A, Pandey AK, Ana GREE, Verma A, Khan AH, Patel DK, Mudiam MKR, Jain SK, Roy R, Dhawan A. 2013. Polycyclic aromatic hydrocarbons and their quinones modulate the metabolic profile and induce DNA damage in human alveolar and bronchiolar cells. Int J Hyg Environ Health. 216(5):553–65.
- Titaley I, Chlebowski A, Truong L, Tanguay RL, SL Massey Simonich. 2016. Identification and toxicological evaluation of unsubstituted PAHs and novel PAH derivatives in pavement sealcoat products. Environ Sci Technol Lett. 3(6):234–42.
- Wang W, Jariyasopit N, Schrlau J, Jia Y, Tao S, Yu T-W, Dashwood RH, Zhang W, Wang S, Massey Simonich SL. 2011. Concentration and photochemistry of PAHs, NPAHs, and OPAHs and toxicity of PM5 during the Beijing Olympic Games. Environ Sci Technol. 45(16):6887–95.
- Wang M, Jia S, Lee SH, Chow A, Fang M. 2020. Polycyclic aromatic hydrocarbons (PAHs) in indoor environments are still imposing carcinogenic risk. J Hay Mater. 409:124531.
Everyday Products
- Popiół J, Gunia-Krzyżak A, Słoczyńska K, Koczurkiewicz-Adamczyk P, Piska K, Wójcik-Pszczoła K, Żelaszczyk D, Krupa A, Żmudzki P, Marona H, Pękala E. 2020. The involvement of xanthone and (E)-cinnamoyl chromophores for the design and synthesis of novel sunscreening agents. Int J Mol Sci. 22(1):34.
- Skrzypczak A, Zawadzki T, Nałęcz-Jawecki G. 2012. Influence of titanium dioxide on the photo-genotoxicity of selected sunscreens under UVA and UVB irradiation investigated with umu-test and Ames MPF™ assay. Fresen Environ Bull. 21(12):3796–803.
- Zappa G, Carconi P, Gatti R, D'Alessio A, Di Bonito R, Mosiello L, Zoani C. 2009. Feasibility study for the development of a toner-Reference Material. Measurements. 42(10):1491–6.
Extracts
- Abudayyak M, Jannuzzi AT, Özhan G, Alpertunga B. 2015. Investigation on the toxic potential of Tribulus terrestris in vitro. Pharm Biol. 53(4):469–76.
- Abudayyak M, Nath EÖ, Özhan G. 2015. Toxic potentials of ten herbs commonly used for aphrodisiac effect in Turkey. Turk J Med Sci. 45(3):496–506.
- Baskaran J, Gnanamani A, Amalan Stanley V, Stanley SA. 2018. Genotoxic evaluation of Rasagenthi Mezhugu, a Siddha formulation, using Salmonella typhimurium strains. Int J Res BioSciences. 7(1):70–6.
- Dziwenka M, Dolan L, Mitchell J. 2021. Toxicological safety of VOHO Hemp Oil; a supercritical fluid extract from the aerial parts of hemp. PLoS One. 16(12): e0261900.
- Karayıldırım ÇK, Güner A, Yiğittürk G, Yavaşoğlu A, Karabay Yavaşoğlu NÜ. 2022. Phytochemistry, Biological Activity and Toxicity of Botanical Dietary Supplement: KL21. Celal Bayar University Journal of Science. 18(1):95–105.
- Katabale MK, Esther NM, Kariuki D. 2017. Phytochemical screening, cytotoxic, genotoxic and mutagenic effects of the aqueous extract of Azadirachta indica leaves. Int J Herb Med. 5(3):39–44.
- Kołodziejski D, Piekarska A, Hanschen FS, Pilipczuk T, Tietz F, Kusznierewicz B, Bartoszek A. 2019. Relationship between conversion rate of glucosinolates to isothiocyanates/indoles and genotoxicity of individual parts of Brassica vegetables. Eur Food Res Technol. 245:383–400.
- Omurtag Özgen PS, Biltekin SN, İduğ T, Macit C, Ayran İ, Çelik SA, Kültür Ş, Kan Y, Omurtag GZ. 2022. Chemical composition and in vitro mutagenic, antioxidant and anti-inflammatory activities of Lavandula angustifolia Mill. essential oil from Turkey. J Res Pharm. 26(4):781–9.
- Rao BS, Chandrasekaran CV, Srikanth HS, Sasikumar M, Jothie RE, Haseena B, Bharathi B, Selvam R, Prashanth D'S. 2018. Mutagenicity and acute oral toxicity test for herbal poultry feed supplements. J Toxicol. 2018:9412167.
Food & Food Contact Material
Food
- Barbezan AB, Martins R, Bueno JB, Villavicencio ALCH. 2017. Ames test to detect mutagenicity of 2‐alkylcyclobutanones: A review. J Food Sci. 82(7):1518–22. [review]
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- Saxena S, Kumar S, Tripathi J, Gautam S. 2017. No induced mutagenesis in human lymphoblast cell line and bacterial systems upon their prolonged sub‐culturing in irradiated food blended media. J Sci Food Agricult. 98(5):2011–9.
- Saxena S, Gautam S, Maru G, Kawle D, Sharma A. 2012. Suppression of error prone pathway is responsible for antimutagenic activity of honey. Food Chem Toxicol. 50(3–4):625–33.
Food Contact Material
- Meyer D, Marin-Kuan M, Debon E, Serrant P, Cottet-Fontannaz C, Schilter B, Morlock GE. 2020. Detection of low levels of genotoxic compounds in food contact materials using an alternative HPTLC-SOS-Umu-C assay. ALTEX. 38(3):387–97.
- Rainer B, Mayrhofer E, Redl M, Dolak I, Mislivececk D, Czerny T, Kirchnawy C, Marin-Kuan M, Schilter B, Tacker M. 2019. Mutagenicity assessment of food contact material migrates with the Ames MPF assay. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 36(9):1419–32.
- Hayrapetyan R, Cariou R, Platel A, Santos J, Huot L, Monneraye V, Chagnon MC, Séverin I. 2024. Identification of non-volatile non-intentionally added substances from polyester food contact coatings and genotoxicity assessment of polyester coating's migrates. Food Chem Toxicol. 185:114484.
Medical Devices
- Major R, Plutecka H, Gruszczynska A, Lackner JM, Major B. 2017. Effects of the surface modification of polyurethane substrates on genotoxicity and blood activation processes. Mater Sci Eng C Mater Biol Appl. 79:756–62.
- More AB, Chilgunde SN, Kamble JC, Patil PS, Malshe VC, Vanage GR, Devarajan PV. 2009. Polyethylene sebacate: Genotoxicity, mutagenicity evaluation and application in periodontal drug delivery system. J Pharm Sci. 98(12):4781–95.
- Pereira I, Fraga S, Silva S, Teixeira JP, Gama M. 2018. In vitro genotoxicity assessment of an oxidized dextrin‐based hydrogel for biomedical applications. J Appl Toxicol. 39(4):639–49.
- Piszczek P, Radtke A, Ehlert M, Jędrzejewski T, Sznarkowska A, Sadowska B, Bartmański M, Erdoğan YK, Ercan B, Jedrzejczyk W. 2020. Comprehensive evaluation of the biological properties of surface-modified titanium alloy implants. J Clin Med. 9(2):342.
- Szymanski L, Gołaszewska K, Wiatrowska A, Dropik M, Krakowiak P, Małkowska J, Matak D. 2022. Biocompatibility of novel albumin‑aldehyde surgical adhesive. Sci Rep. 2(1):12749.
Nanoparticles
- Arasoğlu T, Derman S. 2018. Assessment of the antigenotoxic activity of poly(d,l-lactic-co-glycolic acid) nanoparticles loaded with caffeic acid phenethyl ester using the Ames Salmonella/microsome assay. J Agric Food Chem. 66(24):6196–204.
- More AB, Patel MD, Malshe VC, Devarajan PV, Vanage GR. 2013. Genotoxicity and mutagenicity evaluation of polyethylene sebacate nanoparticles. J Nanopharm Drug Deliv. 1(3):301–10.
- Noddeland HK, Kemp P, Urquhart AJ, Herchenhan A, Rytved KA, Petersson K, Jensen LB. 2022. Reactive oxygen species-responsive polymer nanoparticles to improve the treatment of inflammatory skin diseases. ACS Omega. 7:25055–65.
- Ricotti L, Cafarelli A, Manferdini C, Trucco D, Vannozzi L, Gabusi E, Fontana F, Dolzani P, Saleh Y, Lenzi E, Columbaro M, Piazzi M, Bertacchini J, Aliperta A, Cain M, Gemmi M, Parlanti P, Jost C, Fedutik Y, Nessim GD, Telkhozhayeva M, Teblum E, Dumont E, Delbaldo C, Codispoti G, Martini L, Tschon M, Fini M, Lisignoli G. 2024. Ultrasound Stimulation of Piezoelectric Nanocomposite Hydrogels Boosts Chondrogenic Differentiation in Vitro, in Both a Normal and Inflammatory Milieu. ACS Nano. 18(3):2047-2065.
Statistical Analyses
- Hothorn LA, Spiliotopoulos D. 2020. Similarity of multiple dose-response curves in interlaboratory studies in regulatory toxicology. arXiv. March 22nd, 2022.