XenoScreen - Xenometrix

Chemicals

Czernych R, Chraniuk M, Zagożdżon P, Wolska L. 2017. Characterization of estrogenic and androgenic activity of phthalates by the XenoScreen YES/YAS in vitro assay. Environ Toxicol Pharmacol. 53:95–104.
Kim D-H, Park CG, Kim SH, Kim YJ. 2019. The effects of mono-(2-ethylhexyl) phthalate (MEHP) on human estrogen receptor (hER) and androgen receptor (hAR) by YES/YAS in vitro assay. Molecules. 24(8):1558.
Park CG, Singh N, Ryu CS, Yoon JY, Esterhuizen M, Kima YJ. 2022. Species differences in response to binding interactions of Bisphenol A and its analogs with the modeled estrogen receptor 1 and in vitro reporter gene assay in human and zebrafish. Environ Toxicol Chem. 41(10):2431–43.
Ramírez V, Gálvez-Ontiveros Y, Porras-Quesada P, Martinez-Gonzalez LJ, Rivas A, Álvarez-Cubero MJ. 2021. Metabolic pathways, alterations in miRNAs expression and effects of genetic polymorphisms of bisphenol a analogues: A systematic review. Environ Res. 197:111062.
Rucki M, Kejlova K, Vlkova A, Jirova D, Dvorakova M, Svobodova L, Kandarova H, Letasiova S, Kolarova H, Mannerstrom M, Heinonen T. 2020. Evaluation of toxicity profiles of rare earth elements salts (lanthanides). J Rare Earths. 39(2):225-32.
Skledar DG, Schmidt J, Fic A, Klopčič I, Trontelj J, Dolenc MS, Finel M, Mašič LP. 2016. Influence of metabolism on endocrine activities of bisphenol S. Chemosphere. 157:152–9.

Environment

Abudayyak M, Jannuzzi AT, Özhan G, Alpertunga B. 2015. Investigation on the toxic potential of Tribulus terrestris in vitro. Pharm Biol. 53(4):469–76.
Dong S, Page MA, Hur A, Hur K, Bokenkamp KV, Wagner ED, Plewa MJ, Massalha N. 2021. Comparison of estrogenic, spectroscopic, and toxicological analyses of pilot-scale water, wastewaters, and processed wastewaters at select military installations. Environ Sci Technol. 55(19):13103–13112.
Graça CAL, Ribeirinho-Soares S, Abreu-Silva J, Ramos II, Ribeiro AR, Castro-Silva SM, Segundo MA, Manaia CM, Nunes OC, Silva AMT. 2020. A pilot study combining ultrafiltration with ozonation for the treatment of secondary urban wastewater: Organic micropollutants, microbial load and biological effects. Water. 12(12):3458.
Janicki T, Długoński A, Felczak A, Długoński J, Krupiński M. 2022. Ecotoxicological Estimation of 4-Cumylphenol, 4-t-Octylphenol, Nonylphenol, and Volatile Leachate Phenol Degradation by the Microscopic Fungus Umbelopsis isabellina Using a Battery of Biotests. Int J Environ Res Public Health. 19:4093.
Marika M, Marketa D, Lada S, Marian R, Filip K, Adam V, Věra V, Kristina K, Dagmar J, Tuula H. 2022. New approach methods for assessing indoor air toxicity. Curr Res Toxicol. 3:100090.
Oliver M, Kudłak B, Wieczerzak M, Reis S, Lima SAC, Segundo MA, Miró M. 2020. Ecotoxicological equilibria of triclosan in Microtox, XenoScreen YES/YAS, Caco2, HEPG2 and liposomal systems are affected by the occurrence of other pharmaceutical and personal care emerging contaminants. Sci Tot Env. 719:137358.
Szczepańska N, Kudłak B, Namieśnik J. 2018. Assessing ecotoxicity and the endocrine potential of selected phthalates, BADGE and BFDGE derivatives in relation to environmentally detectable levels. Sci Total Environ. 610–611:854–66.
Wieczerzak M, Namieśnik J, Kudłak B. 2016. Bioassays as one of the Green Chemistry tools for assessing environmental quality: A review. Environ Int. 94:341–61. [review]

Packaging

Szczepańska N, Kudłak B, Tsakovski S, Yotova G, Nedyalkova M, Simeonov V, Dołęga A, Namieśnik J. 2018. Modeling and MANOVA studies on toxicity and endocrine potential of packaging materials exposed to different extraction schemes. Environ Res. 165:294–305.

Pharmaceuticals

Gyovai A, Minorics R, Kiss A, Mernyák E, Schneider G, Szekeres A, Kerekes E, Ocsovszki I, Zupkó I. 2018. Antiproliferative properties of newly synthesized 19-nortestosterone analogs without substantial androgenic activity. Front Pharmacol. 9:825.
Kejlová K, Bendová H, Chrz J, Dvořáková M, Svobodová L, Vlková A, Kubáč L, Kořínková R, Černý J, Očadlíková D, Rucki M, Heinonen T, Jírová D, Letašiová S, Kandarova H, Kolářová H. 2020. Toxicological testing of a photoactive phthalocyanine-based antimicrobial substance. Reg Toxicol Pharmacol. 115:104685.
Kudłak B, Wieczerzak M, Namieśnik J. 2019. Bisphenols (A, S, and F) affect the basic hormonal activity determined for pharmaceuticals – Study of Saccharomyces cerevisiae. Env Pollut. 246:914–20.
Kulmány ÁE, Frank É, Papp D, Szekeres A, Szebeni GJ, Zupkó I. 2021. Biological evaluation of antiproliferative and anti-invasive properties of an androstadiene derivative on human cervical cancer cell lines. J Steroid Biochem Mol Biol. 105990.
Liwarska-Bizukojc E, Stevens CV, Delbeke EIP, Van Geem KM. 2021. Endocrine disrupting potency and toxicity of novel sophorolipid quaternary ammonium salts. Ecotoxicology. 30:658–66.
Wang Y, Liang W. 2021. Occurrence, toxicity, and removal methods of triclosan: a timely review. Curr Pollut Rep. 7:31–9.
Wieczerzak M, Kudłak B, Yotova G, Nedyalkova M, Tsakovski S, Simeonov V, Namieśnik J. 2016. Modeling of pharmaceuticals mixtures toxicity with deviation ratio and best-fit functions models. Sci Total Environ. 571:259–68.
Wieczerzak M, Kudłak B, Yotova G, Tsakovski S, Simeonov V, Namieśnik J. 2018. Impact of inorganic ions and pH variations on toxicity and endocrine potential of selected environmentally relevant pharmaceuticals. Environ Pollut. 237:549–58.

Products (Disinfectants, Food Contact Materials, Plasticizers, Toys)

Briou B, Caillol S, Robin J-J, Lapinte V. 2019. Non-endocrine disruptor effect for cardanol based plasticizer. Industr Crops Products. 130:1–8.
Kejlová K, Dvořáková M, Vavrouš A, Ševčík V, Kanďárová H, Letašiová S, Sosnovcová J, Jírová D. 2019. Toxicity of food contact paper evaluated by combined biological and chemical methods. Toxicol In Vitro. 59:26–34.
Kim D-H, Park CG, Kim YJ. 2020. Characterizing the potential estrogenic and androgenic activities of two disinfection byproducts, mono-haloacetic acids and haloacetamides, using in vitro bioassays. Chemosphere. 242:125198.
Owczarek K, Kudłak B, Simeonov V, Mazerska Z, Namieśnik J. 2018. Binary mixtures of selected bisphenols in the environment: Their toxicity in relationship to individual constituents. Molecules. 23(12):3226.
Park CG, Jung KC, Kim D-H, Kim YJ. 2021. Monohaloacetonitriles induce cytotoxicity and exhibit different mode of action in endocrine disruption. Sci Tot Env. 761:143316.
Szczepańska N, Namieśnik J, Kudłak B. 2016. Assessment of toxic and endocrine potential of substances migrating from selected toys and baby products. Environ Sci Pollut Res. 23(24):24890–900.
Szczepańska N, Kudłak B, Nedyalkova M, Simeonov V, Namieśnik J. 2017. Application of chemometric techniques in studies of toxicity of selected commercially available products for infants and children. Environ Monit Assess. 189(7):309.

pYES, pYAS (HPTLC)

Kruse S, Pierre F, Morlock GE. 2021. Effects of the Probiotic Activity of Bacillus subtilis DSM 29784 in Cultures and Feeding Stuff. J Agric Food Chem. 69(38):11272–81.
Morlock GE, Ziltener A, Geyer S, Tersteegen J, Mehl A, Schreiner T, Kame T,Brümmer F. 2022. Evidence that Indo-Pacific bottlenose dolphins self-medicate with invertebrates in coral reefs. iScience.
Schreiner T, Sauter D, Friz M, Heil J, Morlock GE. 2021. Is our natural food our homeostasis? Array of a thousand effect-directed profiles of 68 herbs and spices. Front Pharmacol. 12:755941.
Schreiner T, Ronzheimer A, Friz M, Morlock GE. 2022. Multiplex planar bioassay with reduced diffusion on normal phase, identifying androgens, verified antiandrogens and synergists in botanicals via 12D hyphenation. Food Chem. 395:133610.

Water

Loffredo E, Castellana G, Taskin E. 2016. A two-step approach to eliminate pesticides and estrogens from a wastewater and reduce its phytotoxicity: adsorption onto plant-derived materials and fungal degradation. Water Air Soil Pollut. 227:188.
Moreira NFF, Sousa JM, Macedo G, Ribeiro AR, Barreiros L, Pedrosa M, Faria JL, Pereira MFR, Castro-Silva S, Segundo MA, Manaia CM, Nunes OC, Silva AMT. 2016. Photocatalytic ozonation of urban wastewater and surface water using immobilized TiO₂ with LEDs: Micropollutants, antibiotic resistance genes and estrogenic activity. Water Res. 94:10–22.